Rabbit CD86 Protein, His Tag_天津卡梅德科技发展有限公司

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Rabbit CD86 Protein, His Tag

Rabbit CD86 Protein, His Tag

产品编号

KMP2297

别名

T 淋巴细胞活化抗原 CD86, T-lymphocyte activation antigen CD86, CD86

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Catalog Number	KMP2297
Alias	T 淋巴细胞活化抗原 CD86, T-lymphocyte activation antigen CD86, CD86
Size	50ug, 100ug, 200ug
Product Description	The Rabbit CD86 Protein(KMP2297) is produced in HEK293 Cells and the target gene encoding Ala23-Arg246 is expressed with a 6His tag at the C-terminus.
Molecular Name	CD86
Product Introduction	CD86（B7-2）：免疫球蛋白超家族跨膜蛋白，与CD80协同作用，提供T细胞活化的共刺激信号。
Molecular Weight	26.27 kDa
Expression System	HEK293 Cells
Species	Rabbit
Purity	>95%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	P42071
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	PBS, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	T-lymphocyte activation antigen CD86(B7-2) is a glycosylated protein in the B7 family. B7 family members are transmembrane cell surface molecules that play important roles in immune activation and the maintenance of immune tolerance. It is highly expressed on activated antigen presenting cells. CD86 involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

如何避免重组蛋白降解？

可在纯化过程中加入蛋白酶抑制剂、低温操作，优化储存条件（如分装冻存于-80°C），并避免反复冻融。某些情况下，可选用蛋白酶缺陷型宿主菌减少降解风险。
如何检测重组蛋白的表达和纯度？

常用SDS-PAGE、Western Blot检测表达，BCA/Bradford法测浓度，HPLC或质谱分析纯度，生物活性实验（如ELISA、酶活检测）验证功能。

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