Human HAVCR2 Protein, mFc Tag_天津卡梅德科技发展有限公司

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Human HAVCR2 Protein, mFc Tag

Human HAVCR2 Protein, mFc Tag

产品编号

KMP2288

别名

甲型肝炎病毒细胞受体 2, Hepatitis A virus cellular receptor 2, HAVCR2

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Catalog Number	KMP2288
Alias	甲型肝炎病毒细胞受体 2, Hepatitis A virus cellular receptor 2, HAVCR2
Size	50ug, 100ug, 200ug
Product Description	The Human HAVCR2 Protein(KMP2288) is produced in HEK293 Cells and the target gene encoding Ser22-Arg200 is expressed with a mFc tag at the C-terminus.
Molecular Name	HAVCR2
Product Introduction	HAVCR2（TIM-3）：免疫调节跨膜蛋白，在耗竭T细胞表面高表达，参与免疫应答的负调控。
Molecular Weight	19.87 kDa
Expression System	HEK293 Cells
Species	Human
Purity	>80%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	Q8TDQ0
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	PBS, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	Hepatitis A virus cellular receptor 2(HAVCR2) is a single-pass type I membrane protein and it contains 1 Ig-like V-type(immunoglobulin-like) domain. The protein belongs to the immunoglobulin superfamily, and TIM family of proteins. The protein regulates macrophage activation. It inhibits T-helper type 1 lymphocyte(Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and it is receptor for LGALS9. CD4(MIM 186940)-positive T helper lymphocytes can be divided into types 1(Th1) and 2(Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

蛋白溶解后浓度偏低，如何调整？

低速离心：12,000 rpm, 5分钟，去除不溶物。缓冲液置换：使用超滤离心管（如10 kDa截留分子量）浓缩。
如何提高重组蛋白的可溶性表达？

可优化表达条件（如降低诱导温度、调整IPTG浓度）、使用促溶标签（如SUMO、GST）、共表达分子伴侣，或尝试不同宿主系统（如哺乳动物细胞或昆虫细胞）以提高可溶性蛋白产量。

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