Human CD252 Protein, mFc Tag_天津卡梅德科技发展有限公司

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Human CD252 Protein, mFc Tag

Human CD252 Protein, mFc Tag

产品编号

KMP2279

别名

肿瘤坏死因子受体超家族成员 4, Tumor necrosis factor ligand superfamily member 4, OX40L

规格

50ug
100ug
200ug

DATASHEET MSDS

立即询价加入询价列表大包装定制

产品介绍

Catalog Number	KMP2279
Alias	肿瘤坏死因子受体超家族成员 4, Tumor necrosis factor ligand superfamily member 4, OX40L
Size	50ug, 100ug, 200ug
Product Description	The Human CD252 Protein(KMP2279) is produced in HEK293 Cells and the target gene encoding Gln51-Leu183 is expressed with a mFc tag at the C-terminus.
Molecular Name	CD252
Product Introduction	CD252（OX40L）：TNF超家族成员，通过跨膜形式作为CD134（OX40）的配体参与T细胞活化。
Molecular Weight	15.43 kDa
Expression System	HEK293 Cells
Species	Human
Purity	>95%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	P23510
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	PBS, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	Tumor necrosis factor ligand superfamily member 4(TNFSF4/OX40L) is a single-pass type II membrane protein.OX40L is expressed on the surface of activated B cells, T cells, dendritic cells and endothelial cells. OX40L binds to OX40(CD134), a member of the TNF receptor superfamily that is expressed predominantly on activated CD4+ T cells. OX40-OX40L co-stimulates signal to promote the survival and proliferation of activated CD4+ T cells and prolong the immune response. It involved in T-cell proliferation and cytokine production. Additional, it has been found association with systemic lupus erythematosus, no association with occurrence of atherosclerosis.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

蛋白溶解后浓度偏低，如何调整？

低速离心：12,000 rpm, 5分钟，去除不溶物。缓冲液置换：使用超滤离心管（如10 kDa截留分子量）浓缩。
如何提高重组蛋白的可溶性表达？

可优化表达条件（如降低诱导温度、调整IPTG浓度）、使用促溶标签（如SUMO、GST）、共表达分子伴侣，或尝试不同宿主系统（如哺乳动物细胞或昆虫细胞）以提高可溶性蛋白产量。

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