Recombinant Human ANGPTL4 Protein, N-His Tag
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产品编号
KMP2268
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别名
血管生成素样蛋白4, Angiopoietin-related protein 4, 425O18-1, Angiopoietin-like protein 4, ANGPTL4
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规格
- 20ug
- 50ug
- 100ug
- 200ug
- 1mg
产品介绍
| Catalog Number | KMP2268 |
| Alias | 血管生成素样蛋白4, Angiopoietin-related protein 4, 425O18-1, Angiopoietin-like protein 4, ANGPTL4 |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | Recombinant Human Angiopoietin Like protein 4 is produced by our Mammalian expression system and the target gene encoding Pro166-Ser406 is expressed with a 6His tag at the N-terminus. |
| Molecular Name | ANGPTL4 |
| Product Introduction | The Human ANGPTL4 Protein(KMP2268) is produced in HEK293 Cells and the target gene encoding Pro166-Ser406 is expressed with a 6His tag at the N-terminus. |
| Molecular Weight | 32-38 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | >95% as determined by SDS-PAGE |
| SDS-PAGE | |
| Purification | Affinity Purification |
| Uniprot ID | Q9BY76 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Angiopoietin-related protein 4(ANGPTL4)is a secreted protein and contains 1 fibrinogen C-terminal domain. The protein may act as a regulator of angiogenesis and modulate tumorigenesis. It inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 may exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity(By similarity). In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix(ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation. |
| Endotoxin | < 0.1 EU per ug |
| Protein Family | Immune checkpoint family, Immunoglobulin superfamily |
| Biological Activity | Immobilized Human ANGPTL4 at 1 μg/mL, 100 μL/well, can bind the Human LILRB2 with an ED50 of 70-350 ng/mL. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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