Cynomolgus TNFSF18 Protein, His Tag_天津卡梅德科技发展有限公司

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Cynomolgus TNFSF18 Protein, His Tag

Cynomolgus TNFSF18 Protein, His Tag

产品编号

KMP2266

别名

肿瘤坏死因子配体超家族成员 18, Tumor necrosis factor ligand superfamily member 18, Tumor necrosis factor ligand superfamily member 18, TNFSF18

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Catalog Number	KMP2266
Alias	肿瘤坏死因子配体超家族成员 18, Tumor necrosis factor ligand superfamily member 18, Tumor necrosis factor ligand superfamily member 18, TNFSF18
Size	50ug, 100ug, 200ug
Product Description	The Cynomolgus TNFSF18 Protein(KMP2266) is produced in HEK293 Cells and the target gene encoding Glu74-Ser199 is expressed with a 6His tag at the C-terminus.
Molecular Name	TNFSF18
Product Introduction	TNFSF18（GITRL）：TNF超家族II型跨膜蛋白，作为GITR配体参与调节性T细胞功能。
Molecular Weight	14.52 kDa
Expression System	HEK293 Cells
Species	Cynomolgus
Purity	>95%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	A0A2K5UCD9
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	PBS, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	TNFSF18 is a single-pass type II membrane protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 cytokine binds to TNFRSF18/AITR/GITR. It regulates T-cell responses, and functions as costimulator and lower the threshold for T-cell activation and T-cell proliferation. It is Important for interactions between activated T-lymphocytes and endothelial cells and Promotes leukocyte adhesion to endothelial cells. TNFSF18 mediates activation of NF-kappa-B. As Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. It also regulates migration of monocytes from the splenic reservoir to sites of inflammation.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

如何储存293F细胞中表达的蛋白？

蛋白可以在-80°C下储存以便长期保存。应分装并避免冻融循环，以保持蛋白的稳定性。
如何提高293F细胞中的蛋白表达效率？

可以通过优化质粒设计、使用高效转染试剂、优化细胞培养条件以及使用蛋白折叠伴侣或密码子优化来提高蛋白表达效率。

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