Cynomolgus CD33L3 Protein, His Tag_天津卡梅德科技发展有限公司

>>

>>

>>

>

Cynomolgus CD33L3 Protein, His Tag

Cynomolgus CD33L3 Protein, His Tag

产品编号

KMP2264

别名

唾液酸结合免疫球蛋白样凝集素-15, Sialic acid-binding Ig-like lectin 15, Siglec-15

规格

50ug
100ug
200ug

DATASHEET MSDS

立即询价加入询价列表大包装定制

产品介绍

Catalog Number	KMP2264
Alias	唾液酸结合免疫球蛋白样凝集素-15, Sialic acid-binding Ig-like lectin 15, Siglec-15
Size	50ug, 100ug, 200ug
Product Description	The Cynomolgus CD33L3 Protein(KMP2264) is produced in HEK293 Cells and the target gene encoding Phe20-Thr263 is expressed with a 6His tag at the C-terminus.
Molecular Name	CD33L3
Product Introduction	CD33L3（Siglec-3L）：免疫球蛋白超家族（IgSF）成员，通过跨膜形式参与髓系细胞功能调节。
Molecular Weight	27.5 kDa
Expression System	HEK293 Cells
Species	Cynomolgus
Purity	>95%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	A0A2K5UY47
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	PBS, 150mM Nacl, 0.3% Chaps, 5% Trehalose, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO--terminus is cytosolic. Each Siglec contains an N-terminal V-type immunoglobulin domain(Ig domain) which acts as the binding receptor for sialic acid. These lectins are placed into the group of I-type lectins because the lectin domain is an immunoglobulin fold. All Siglecs are extended from the cell surface by C2-type Ig domains which have no binding activity. Siglecs differ in the number of these C2-type domains. Human Siglec-15 consists of a 244 amino acid(aa) extracellular domain(ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 function is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

如何避免重组蛋白降解？

可在纯化过程中加入蛋白酶抑制剂、低温操作，优化储存条件（如分装冻存于-80°C），并避免反复冻融。某些情况下，可选用蛋白酶缺陷型宿主菌减少降解风险。
如何检测重组蛋白的表达和纯度？

常用SDS-PAGE、Western Blot检测表达，BCA/Bradford法测浓度，HPLC或质谱分析纯度，生物活性实验（如ELISA、酶活检测）验证功能。

推荐产品

400-621-6806
18630936064（微信同号）
周一至周五 8:30-18:00
0