Human CD70 Protein, mFc Tag_天津卡梅德科技发展有限公司

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Human CD70 Protein, mFc Tag

Human CD70 Protein, mFc Tag

产品编号

KMP2255

别名

肿瘤坏死因子配体超家族成员 7, Tumor necrosis factor ligand superfamily member 7, CD70

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Catalog Number	KMP2255
Alias	肿瘤坏死因子配体超家族成员 7, Tumor necrosis factor ligand superfamily member 7, CD70
Size	50ug, 100ug, 200ug
Product Description	The Human CD70 Protein(KMP2255) is produced in HEK293 Cells and the target gene encoding Gln45-Pro193 is expressed with a mFc tag at the C-terminus.
Molecular Name	CD70
Product Introduction	CD70：TNF超家族II型跨膜蛋白，选择性表达于活化淋巴细胞，作为CD27配体参与免疫记忆形成。
Molecular Weight	16.44 kDa
Expression System	HEK293 Cells
Species	Human
Purity	>95%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	P32970
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	PBS, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	CD27 Ligand(CD70) is a 30 kDa type 2 transmembrane glycoproteinis that belongs to the tumor necrosis factor(TNF) ligand family.Human CD27 Ligand extracellular region is 64% aa identical to mouse and rat CD27 Ligand extracellular regions. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

蛋白溶解后浓度偏低，如何调整？

低速离心：12,000 rpm, 5分钟，去除不溶物。缓冲液置换：使用超滤离心管（如10 kDa截留分子量）浓缩。
如何提高重组蛋白的可溶性表达？

可优化表达条件（如降低诱导温度、调整IPTG浓度）、使用促溶标签（如SUMO、GST）、共表达分子伴侣，或尝试不同宿主系统（如哺乳动物细胞或昆虫细胞）以提高可溶性蛋白产量。

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