Human CD3E Protein, mFc Tag_天津卡梅德科技发展有限公司

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Human CD3E Protein, mFc Tag

Human CD3E Protein, mFc Tag

产品编号

KMP2249

别名

T细胞表面糖蛋白CD3ε链, T-Cell Surface Glycoprotein CD3 Epsilon Chain, CD3E

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Catalog Number	KMP2249
Alias	T细胞表面糖蛋白CD3ε链, T-Cell Surface Glycoprotein CD3 Epsilon Chain, CD3E
Size	50ug, 100ug, 200ug
Product Description	The Human CD3E Protein(KMP2249) is produced in HEK293 Cells and the target gene encoding Gln22-Thr48 is expressed with a mFc tag at the C-terminus.
Molecular Name	CD3E
Product Introduction	CD3E：T细胞受体复合物的核心组分，以跨膜形式参与TCR信号传导，在T细胞活化和免疫应答中起关键作用。
Molecular Weight	2.84 kDa
Expression System	HEK293 Cells
Species	Human
Purity	>95%
Purification	Affinity Purification
Uniprot ID	P07766
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	PBS, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	T-Cell Surface Glycoprotein CD3 ε Chain(CD3ε) is a single-pass type I membrane protein. CD3ε contains 1 Ig-like(immunoglobulin-like) domain and 1 ITAM domain. CD3ε is a polypeptide encoded by the CD3E gene on chromosome 11 in humans. The T cell receptor-CD3 complex(TCR/CD3 complex) is involved in T-cell development and several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs(ITAMs). TCR/CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

如何提高重组蛋白的可溶性表达？

可优化表达条件（如降低诱导温度、调整IPTG浓度）、使用促溶标签（如SUMO、GST）、共表达分子伴侣，或尝试不同宿主系统（如哺乳动物细胞或昆虫细胞）以提高可溶性蛋白产量。
重组蛋白纯化常用的方法有哪些？

常用的纯化方法包括亲和层析（如His-Tag、GST-Tag）、离子交换层析、疏水相互作用层析（HIC）和凝胶过滤层析。具体方法取决于蛋白特性和标签类型。

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