Human Biotinylated CD28 Protein, Fc Tag, Avi Tag_天津卡梅德科技发展有限公司

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Human Biotinylated CD28 Protein, Fc Tag, Avi Tag

Human Biotinylated CD28 Protein, Fc Tag, Avi Tag

产品编号

KMP2236

别名

T细胞特异性表面糖蛋白CD28, CD28 molecule, Tp44

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Catalog Number	KMP2236
Alias	T细胞特异性表面糖蛋白CD28, CD28 molecule, Tp44
Size	50ug, 100ug, 200ug
Product Description	The Human Biotinylated CD28 Protein(KMP2236) is produced in HEK293 Cells and the target gene encoding Asn19-Pro152 is expressed with a Fc, Avi tag at the C-terminus.
Molecular Name	CD28
Product Introduction	CD28：免疫球蛋白超家族（IgSF）成员，以跨膜形式作为重要的共刺激受体参与T细胞活化。
Molecular Weight	15.15 kDa
Expression System	HEK293 Cells
Species	Human
Purity	>95%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	P10747
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	20mM Tris-HCl, 150mM NaCl, pH8.0
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type(immunoglobulin-like) domain. It belongs to the immunoglobulin(Ig) superfamily. CD28 is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 co-stimulation is necessary for CD4 positive T-cell proliferation and survival, interleukin-2 production, and T-helper type-2 development. Human post-thymic regulatory T cells require CD28 co-stimulation to expand and maintain potent suppressive function in vivo. Apoptosis plays a key role in the age-related decline of CD28 expression and in immunosenescence. CD28 is the receptor for CD80(B7.1) and CD86(B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells(APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

如何储存293F细胞中表达的蛋白？

蛋白可以在-80°C下储存以便长期保存。应分装并避免冻融循环，以保持蛋白的稳定性。
如何提高293F细胞中的蛋白表达效率？

可以通过优化质粒设计、使用高效转染试剂、优化细胞培养条件以及使用蛋白折叠伴侣或密码子优化来提高蛋白表达效率。

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