Recombinant Human ACVR1 Protein, C-hFc and His tag
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产品编号
KMH632
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别名
ACVR1受体, FOP, ALK2, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2, activin A receptor type 1
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规格
- 20ug
- 50ug
- 100ug
- 200ug
- 1mg
产品介绍
| Catalog Number | KMH632 |
| Alias | ACVR1受体, FOP, ALK2, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2, activin A receptor type 1 |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | KMH632 Recombinant Human ACVR1 Protein, C-hFc and His tag contains the human ACVR1(23-124 aa & 120-124aa) was expressed in Mammalian cells. |
| Molecular Name | ACVR1 |
| Product Introduction | (KMH632) ACVR1作为一种受体，在胚胎发育和组织生成中起着重要作用。 |
| Molecular Weight | 40-45 kDa and 34-48 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Purification | Affinity Purification |
| Uniprot ID | Q04771 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | ACVR1 is a receptor serine/threonine kinase that is member of the ACVR family and is upstream of signaling pathway involving the SMAD proteins especially SMAD1/5/8. Knockdown of ACVR1, but not TGFβRI (ACVR1), abrogates endoglin-mediated decrease in cell motility of prostate cancer cells and constitutively active ACVR1 is sufficient to restore a low-motility phenotype in endoglin deficient cells. Therefore, endoglin decreases prostate cancer cell motility through activation of the ACVR-Smad1 pathway. ACVR1 is the key gene involved in Fibrodysplasia ossificans progressiva (FOP), a rare autosomal dominant congenital disorder characterized by progressive heterotopic bone formation in muscle tissues. |
| Endotoxin | < 0.1 EU per ug |
| Protein Family | Other protein |
| Biological Activity | Measured by its binding ability in a functional ELISA. When Recombinant Human BMP-6 is used at 0.25 μg/mL, the concentration of Recombinant Human Activin RIA/ALK-2 Fc Chimera that produces 50% of the optimal binding response is found to be approximately 1 |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
FAQ
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已表达的蛋白能否用于疫苗开发？
是的，重组蛋白可以用于疫苗的开发，特别是在生产抗原性蛋白和研究免疫反应方面。
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