Recombinant Human HAVCR2 Protein, C-hFc and His tag_天津卡梅德科技发展有限公司

Recombinant Human HAVCR2 Protein, C-hFc and His tag

产品编号

KMH513

别名

肝脏糖类抗原受体2, TIM3, CD366, KIM 3, SPTCL, TIMD3, Tim 3, TIMD 3, HAVcr 2, hepatitis A virus cellular receptor 2

规格

20ug
50ug
100ug
200ug
1mg

DATASHEET MSDS

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产品介绍

Catalog Number	KMH513
Alias	肝脏糖类抗原受体2, TIM3, CD366, KIM 3, SPTCL, TIMD3, Tim 3, TIMD 3, HAVcr 2, hepatitis A virus cellular receptor 2
Size	20ug, 50ug, 100ug, 200ug, 1mg
Product Description	KMH513 Recombinant Human HAVCR2 Protein, C-hFc and His tag contains the human HAVCR2(Ser22-Arg200) was expressed in Mammalian cells.
Molecular Name	HAVCR2
Product Introduction	HAVCR2 (KMH513) 是一种免疫抑制受体，参与调节免疫耐受和自我免疫反应。
Molecular Weight	60-80 kDa
Expression System	HEK293F Cells
Species	Human
Concentration	联系销售经理获得最新批次的浓度
Purity	≥95%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	Q8TDQ0
Storage Condition	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles.
Formulation	Supplied as solution form in 50 mM Tris-HCl, pH 8.0, 150 mM NaCl./ Lyophilized from 50 mM Tris-HCl, pH 8.0, 150 mM NaCl.
Shipping Condition	This product is shipped on ice packs or dry ice.
Background	Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. It was the first surface molecule that specifically identifies Th1 cells in both mice and human. Recently, identification of Galectin-9 as a ligand for TIM-3 has established the TIM-3-Galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFNgamma secretion and influences the ability to induce T cell tolerance in both mice and man.
Endotoxin	< 0.1 EU per ug
Protein Family	Antibody drug target protein
Biological Activity	Immobilized Human Galectin9 at 2 μg/mL can bind recombinant human HAVCR2 with a linear range of 0.3-5 μg/mL.
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。