Recombinant Human APP Protein, C-His tag
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产品编号
KMH507
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别名
淀粉样前体蛋白, AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN II, preA4, CTFgamma, amyloid beta precursor protein
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规格
- 20ug
- 50ug
- 100ug
- 200ug
- 1mg
产品介绍
| Catalog Number | KMH507 |
| Alias | 淀粉样前体蛋白, AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN II, preA4, CTFgamma, amyloid beta precursor protein |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | KMH507 Recombinant Human APP Protein, C-His tag contains the human APP(1-688 aa) was expressed in Mammalian cells. |
| Molecular Name | APP |
| Product Introduction | APP (KMH507) 是参与神经退行性疾病（如阿尔茨海默病）中的一种重要蛋白，参与β-淀粉样蛋白的形成。 |
| Molecular Weight | 100-120 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE | |
| Purification | Affinity Purification |
| Uniprot ID | P05067 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP6 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. |
| Endotoxin | < 0.1 EU per ug |
| Protein Family | Antibody drug target protein |
| Biological Activity | Measured by its ability to inhibit trypsin cleavage of a fluorogenic peptide substrate, Mca-RPKPVENval-WRK(Dnp)- NH2. The IC50 value is < 0.24 nM. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
FAQ
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可以在293F细胞中共表达多种蛋白吗？
是的，293F细胞可以共表达多种蛋白，但可能需要优化共转染条件（如质粒比例、转染条件）以获得高表达水平。
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在293F蛋白表达中常见的问题有哪些？
常见问题包括低蛋白产量、蛋白折叠不良、聚集和蛋白降解。通过优化转染条件和蛋白纯化方案可以解决这些问题。
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- 电话：400-621-6806
- 手机：13116038708
- 邮箱：info@kmdbioscience.com
- 地址：天津市武清区国际企业社区A5栋
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