Recombinant Human CD295/LEPR Protein, His Tag_天津卡梅德科技发展有限公司

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Recombinant Human CD295/LEPR Protein, His Tag

Recombinant Human CD295/LEPR Protein, His Tag

产品编号

KMH440

别名

OBR, OB R, CD295, LEP R, LEPRD, leptin receptor

规格

50ug
100ug

DATASHEET MSDS

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产品介绍

Alias	OBR, OB R, CD295, LEP R, LEPRD, leptin receptor
Catalog Number	KMH440
Molecular Name	LEPR
Species	Human
Host	Mammalian cells
Size	50ug, 100ug
Protein Family	CD molecule
Purity	≥90% as determined by SDS-PAGE
Purification	Affinity Purification
Endotoxin	< 1.0 EU per ug of the protein as determined by the LAL method.
Formulation	PBS
Background	Leptin receptor (LEPR), also known as OB-R and B219, is a single-transmembrane domain receptor of the cytokine receptor family. Leptin receptor exists as homodimer and binds Leptin with high affinity, thus mediates the biological function of the adipocyte-specific hormone Leptin. LEPR is expressed at high levels in hematopoietic stem cells, lymphohematopoietic cell lines, as well as adult reproductive organs. Several isoforms of LEPR have been identified, and LEPR structurally contains two hemopoietin receptor domains, a fibronectin type III domain and a WSXWS domain within the extracellular region. Interaction of leptin and leptin receptor is crucial for body weight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure. Meanwhile, research data supports a leptin receptor activation model based on ligand-induced conformational changes.
Storage Condition	Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles.
Shipping Condition	This product is shipped on ice packs or dry ice.
Molecular Weight	92.29 kDa
Note	仅供科研使用

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