Recombinant Human CD266/TNFRSF12A Protein, C-hFc and His tag
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产品编号
KMH415
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别名
肿瘤坏死因子受体超家族成员12A, FN14, CD266, TWEAKR, TNF receptor superfamily member 12A
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规格
- 20ug
- 50ug
- 100ug
- 200ug
- 1mg
产品介绍
| Catalog Number | KMH415 |
| Alias | 肿瘤坏死因子受体超家族成员12A, FN14, CD266, TWEAKR, TNF receptor superfamily member 12A |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | KMH415 Recombinant Human CD266/TNFRSF12A Protein, C-hFc and His tag contains the human TNFRSF12A(Glu28-Trp79) was expressed in Mammalian cells. |
| Molecular Name | TNFRSF12A |
| Product Introduction | TNFRSF12A在免疫应答中起到重要的调节作用，调节细胞生长与分化。 |
| Molecular Weight | 35-45 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥92% |
| SDS-PAGE |  |
| Purification | Affinity Purification |
| Uniprot ID | Q9NP84 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | TNFSF12 is a cytokine that is part of the TNF ligand family. TNFSF12 is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. TNFSF12 induces apoptosis through multiple pathways of cell death in a cell type-specific manner. TNFSF12 promotes proliferation and migration of endothelial cells, and therefore acts as a regulator of angiogenesis. TNFSF12 is expressed in adult heart, pancreas, skeletal muscle, small intestine, spleen and peripheral blood lymphocytes. TWEAK h induces NFkB and chemokine secretion. TNFSF12 exerts an apoptotic activity in HT-29 human adenocarcinoma cells whilst cultured in the presence of IFN. TNFSF12 promotes proliferation and migration of endothelial cells. |
| Endotoxin | < 0.1 EU per ug |
| Protein Family | CD molecule |
| Biological Activity | Measured by its ability to inhibit TWEAK-induced apoptosis in HT-29 human colon adenocarcinoma cells. The ED50 for this effect is 2-10 ug/mL in the presence of human TWEAK. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
FAQ
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如何判断蛋白是否有抗体反应性？
可以使用ELISA、Western blot或免疫沉淀等技术来检测蛋白与特定抗体的结合反应性。
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如何避免蛋白在纯化过程中的损失？
使用温和的纯化条件、优化缓冲液成分和减少操作步骤，可以有效减少蛋白的损失。
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