Recombinant Human CD80 Protein, C-His tag_天津卡梅德科技发展有限公司

Recombinant Human CD80 Protein, C-His tag

产品编号

KMH245

别名

CD80抗原, B7, BB1, B7 1, B7.1, LAB7, CD28LG, CD28LG1, CD80 molecule

规格

20ug
50ug
100ug
200ug
1mg

DATASHEET MSDS

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产品介绍

Catalog Number	KMH245
Alias	CD80抗原, B7, BB1, B7 1, B7.1, LAB7, CD28LG, CD28LG1, CD80 molecule
Size	20ug, 50ug, 100ug, 200ug, 1mg
Product Description	KMH245 Recombinant Human CD80 Protein, C-His tag contains the human CD80(35-242 aa) was expressed in Mammalian cells.
Molecular Name	CD80
Product Introduction	(KMH245) CD80在B细胞和T细胞之间提供共刺激信号，促进免疫反应的启动。
Molecular Weight	40-50 kDa
Expression System	HEK293F Cells
Species	Human
Concentration	联系销售经理获得最新批次的浓度
Purity	≥95%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	P33681
Storage Condition	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles.
Formulation	PBS, pH7.5
Shipping Condition	This product is shipped on ice packs or dry ice.
Background	It is widely accepted that T cells require a signal induced by the engagement of the T cell receptor and a "costimulatory" signal(s) through distinct T cell surface molecules for optimal T cell expansion and activation. Members of the B7 superfamily of counterreceptors were identified by their ability to interact with costimulatory molecules found on the surface of T cells. Members of the B7 superfamily include B7-1 (CD8), B7-2 (CD86), B7-H1 (PD-L1), B7-H2 (B7RP-1), B7-H3 and PD-L2. B7-1 is expressed on activated B cells, activated T cells, mature dendritic cells and macrophages. T cells express two different receptors capable of binding B7-1, CD28 and CTLA-4. CTLA-4 binds to B7-1 with a 2 - 1 fold higher affinity than CD28. Engagement of CD28 by B7-1 increases T cell proliferation and IL-2 production and enhances the immune response. In contrast, engagement of CTLA-4 is involved in the down-regulation of the immune response. Rat and human B7-1 share 47% amino acid identity.
Endotoxin	< 0.1 EU per ug
Protein Family	CD molecule
Biological Activity	Immobilized Recombinant human CD80 at 2 μg/mL (100 μL/well) can bind Recombinant human CTLA-4 with a linearrange of 10-50 ng/mL.
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。