Recombinant Human CD50/ICAM3 Protein, C-hFc and His tag
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产品编号
KMH213
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别名
ICAM3抗原, CD50, CDW50, ICAM R, intercellular adhesion molecule 3
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规格
- 20ug
- 50ug
- 100ug
- 200ug
- 1mg
产品介绍
| Catalog Number | KMH213 |
| Alias | ICAM3抗原, CD50, CDW50, ICAM R, intercellular adhesion molecule 3 |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | KMH213 Recombinant Human CD50/ICAM3 Protein, C-hFc and His tag contains the human ICAM3(30-485aa) was expressed in Mammalian cells. |
| Molecular Name | ICAM3 |
| Product Introduction | (KMH213) ICAM3在白血球上表达，参与白血球迁移和免疫反应的调节。 |
| Molecular Weight | 110-130 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE | |
| Purification | Affinity Purification |
| Uniprot ID | P32942 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | The protein ICAM3, also known as CD5, is a member of the intercellular adhesion molecule (ICAM) family consisting three members. All ICAM proteins are type I transmembrane glycoproteins, and are ligands for leukocyte function-associated antigen 1 (LFA-1) expressed on the surface of all white blood cells. ICAM-3 comprises of five immunoglobulin-like domains, and binds LFA-1 through its two N-terminal domains. It functions not only as an adhesion molecule, but also as a potent signalling molecule.ICAM3 is constitutively and abundantly expressed by all leucocytes, and thus is the major ligand for LFA-1 in the initiation of primary immune responses. It has been reported that CD5 molecule can play a role in developing functionally mature T lymphocytes and its expression increases during the maturation process of T lymphocytes. In addition, the interactions of ICAM-3 and LFA-1 facilitate HIV-1- induced virological synapse formation between T cells |
| Endotoxin | < 0.1 EU per ug |
| Protein Family | CD molecule |
| Biological Activity | Measured by the ability of the immobilized protein to support the adhesion of THP-1 cells. When cells are added to ICAM-3 coated plates (12.5 μg/mL, 100 μL/well),approximately >50% cells will adhere specifically after 60 minutes at 37 ℃. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
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