Recombinant Human CD33 Protein, C-hFc and His tag
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产品编号
KMH188
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别名
CD33抗原, p67, SIGLEC3, SIGLEC 3, CD33 molecule
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规格
- 20ug
- 50ug
- 100ug
- 200ug
- 1mg
产品介绍
| Catalog Number | KMH188 |
| Alias | CD33抗原, p67, SIGLEC3, SIGLEC 3, CD33 molecule |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | KMH188 Recombinant Human CD33 Protein, C-hFc and His tag contains the human CD33(Asp18-His259) was expressed in Mammalian cells. |
| Molecular Name | CD33 |
| Product Introduction | CD33 (KMH188) 在免疫反应中发挥作用，参与白血球的分化和功能调节。 |
| Molecular Weight | 65-75 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Purification | Affinity Purification |
| Uniprot ID | P20138 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Myeloid?cell?surface?antigen CD33 also known as SIGLEC3, Siglecs?(sialic?acid?binding?Ig-like?lectins) and?GP67, is a single-pass type I membrane protein which belongs to the?immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Human CD33 / Siglec-3 cDNA encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N--terminal Ig--like V--type domain, one Ig--like C2--type domains, a transmembrane region and a cytoplasmic tail. CD33 / Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells. In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia. |
| Endotoxin | < 0.1 EU per ug |
| Protein Family | CD molecule |
| Biological Activity | Measured by the ability of the immobilized protein to support the adhesion of human red blood cells. The ED50 for this effect is 1‑4 µg/mL. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
FAQ
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蛋白存放时能否与其他蛋白混合存储？
不建议将不同的蛋白混合存放，特别是在不同的纯化状态下，以避免相互作用或降解。
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- 手机：13116038708
- 邮箱：info@kmdbioscience.com
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400-621-6806 -
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