Recombinant Human SERPING1 Protein, C-His tag
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产品编号
KMH1705
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别名
C1抑制蛋白, C1IN, C1NH, HAE1, HAE2, C1INH, serpin family G member 1
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规格
- 20ug
- 50ug
- 100ug
- 200ug
- 1mg
产品介绍
| Catalog Number | KMH1705 |
| Alias | C1抑制蛋白, C1IN, C1NH, HAE1, HAE2, C1INH, serpin family G member 1 |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | KMH1705 Recombinant Human SERPING1 Protein, C-His tag contains the human SERPING1(23-500 aa) was expressed in Mammalian cells. |
| Molecular Name | SERPING1 |
| Product Introduction | SERPING1 (KMH1705) 主要通过抑制补体系统发挥作用，参与免疫反应的调节。 |
| Molecular Weight | 90-110 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Purification | Affinity Purification |
| Uniprot ID | P05155 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | C1 Inhibitor is a member of the serpin family of structurally related proteins, and is the primary regulator of the immune complement system. C1Inhibitor is a protease inhibitor that functions to inhibit the complement system in order to prevent over-activation or spontaneous activation. Inhibition is achieved by binding to and irreversibly inhibiting the C1r and C1s proteases of the C1 complex, which has the effect of shutting down all subsequent downstream events in the complement activation cascade. C1inhibitor can also inhibit various other proteases, including Kallikrein, Factor XIa, and Factor XIIa. Deficiencies in C1inhibitor are the primary cause of hereditary angioedema (HAE, hereditary angioneurotic edema), a disease characterized by edema in the respiratory and gastrointestinal tracts. In certain clinical situations, the direct administration of C1inhibitor can be used to treat HAE and certain other conditions. |
| Endotoxin | < 0.1 EU per ug |
| Protein Family | Other protein |
| Biological Activity | Measured by its ability to inhibit Recombinant Human Complement Component C1s cleavage of a colorimetric peptide substrate, Ncarbobenzyloxy-Lys-ThioBenzyl ester(Z-K-SBzl). The IC50 is <5 nM, as measured underthe described conditions. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
FAQ
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如何确保蛋白表达的质量？
通过优化表达条件、使用高质量的培养基和转染试剂，并通过纯化后检测蛋白的活性和纯度来确保蛋白质量。
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