Recombinant Human NRG1 Protein, C-His tag
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产品编号
KMH1473
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别名
NRG1, GGF, HGL, HRG, NDF, ARIA, GGF2, HRG1, HRGA, SMDF, MST131, MSTP131, NRG1 IT2, neuregulin 1
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规格
- 20ug
- 50ug
- 100ug
- 200ug
- 1mg
产品介绍
| Catalog Number | KMH1473 |
| Alias | NRG1, GGF, HGL, HRG, NDF, ARIA, GGF2, HRG1, HRGA, SMDF, MST131, MSTP131, NRG1 IT2, neuregulin 1 |
| Size | 20ug, 50ug, 100ug, 200ug, 1mg |
| Product Description | KMH1473 Recombinant Human NRG1 Protein, C-His tag contains the human NRG1(20-241 aa) was expressed in Mammalian Cells. |
| Molecular Name | NRG1 |
| Product Introduction | (KMH1473) NRG1在神经发育中起着重要作用，并在一些神经疾病中起关键作用。 |
| Molecular Weight | 40-43 kDa |
| Expression System | HEK293F Cells |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | ≥95% |
| SDS-PAGE |  |
| Purification | Affinity Purification |
| Uniprot ID | Q02297 |
| Storage Condition | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -20℃. Avoid repeated freeze-thaw cycles. |
| Formulation | PBS |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms release soluble growth factors. HRG1-β1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity, which leads to tyrosine phosphorylation. |
| Endotoxin | < 0.1 EU per ug |
| Protein Family | Other protein |
| Biological Activity | Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The ED50 forthis effect is 20‑100 ng/mL. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
FAQ
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如何判断蛋白是否有抗体反应性？
可以使用ELISA、Western blot或免疫沉淀等技术来检测蛋白与特定抗体的结合反应性。
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如何避免蛋白在纯化过程中的损失？
使用温和的纯化条件、优化缓冲液成分和减少操作步骤，可以有效减少蛋白的损失。
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