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Recombinant Human HPGD Protein, His Tag

Recombinant Human HPGD Protein, His Tag

产品编号

KMH1223

别名

PGDH, PGDH1, PHOAR1, 15 PGDH, SDR36C1, 15 hydroxyprostaglandin dehydrogenase

规格
  • 50ug
  • 100ug
产品介绍
AliasPGDH, PGDH1, PHOAR1, 15 PGDH, SDR36C1, 15 hydroxyprostaglandin dehydrogenase
Catalog NumberKMH1223
Molecular NameHPGD
SpeciesHuman
HostMammalian cells
Size50ug, 100ug
Protein FamilyOther protein
Purity≥90% as determined by SDS-PAGE
PurificationAffinity Purification
Endotoxin< 1.0 EU per ug of the protein as determined by the LAL method.
FormulationPBS
BackgroundNAD+-dependent 15-hydroxy prostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation of PGs to 15-keto metabolites that have greatly reduced biological activity. Human NAD+-dependent 15-PGDH is a 266 amino acid protein with a molecular weight of 29 kDa and is expressed in multiple tissues including lung, placenta, and kidney. The enzyme belongs to a large family of short-chain alcohol dehydrogenases, which exhibit amino acid identity ranging from 15-3%. Recent studies indicate 15-PGDH may play a role as a tumor suppressor. Studies have shown an inverse correlation between 15-PGDH expression and cell proliferation in colon, breast, and thyroid cells. 15-PGDH specific activity was determined using PGE2 as the substrate and NAD+ as the cofactor and was calculated after subtracting the mass contribution form the GST tag.
Storage ConditionStore the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles.
Shipping ConditionThis product is shipped on ice packs or dry ice.
Molecular Weight29.26 kDa
Note仅供科研使用

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