Recombinant Human IL4 Protein, C-His tag
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产品编号
KMH114
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别名
重组人IL-4蛋白，Interleukin-4, IL-4, B-cell stimulatory factor 1, Binetrakin
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规格
- 100ug
- 500ug
- 1mg
产品介绍
| Catalog Number | KMH114 |
| Alias | 重组人IL-4蛋白，Interleukin-4, IL-4, B-cell stimulatory factor 1, Binetrakin |
| Size | 100ug,500ug,1mg |
| Product Full Name | Recombinant Human IL-4 Protein |
| Molecular Name | IL4 |
| Product Introduction | 重组人白介素-4，是促进B细胞增殖和Th2细胞分化的关键因子。适用于过敏与免疫调节研究、B细胞抗体产生实验及寄生虫免疫模型。 |
| Molecular Weight | 14 kDa |
| Target | IL-4 |
| Expression System | E.coli |
| Species | Human |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purity | >97%, determined by SDS-PAGE. |
| Purification | Affinity Purification |
| Uniprot ID | P05112 |
| Storage Condition | Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
| Temperature Range | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -31℃. Avoid repeated freeze-thaw cycles. |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Background | 一种关键的2型免疫反应（Th2）细胞因子，由Th2细胞、嗜碱性粒细胞等产生，主要功能是促进B细胞类别转换为产生IgE抗体，并参与过敏反应和抗寄生虫免疫。 |
| Endotoxin | <0.01 EU/μg, determined by LAL method. |
| Predicted Molecular Weight | 15.1 kDa |
| Application | WB, ELISA |
| Reconstitution | It is recommended that the lyophilized human IL-4 protein be dissolved in PBS at a concentration of 100-200 μg/ml for further dilution as the working concentration. |
| Stability | Repeated freezing and thawing is not recommended. |
| References | 1. Benczik, M. and S.L. Gaffen (2004) Immunol. Invest. 33:109. 2. Chomarat, P. and J. Banchereau (1998) Int. Rev. Immunol. 17:1. 3. Yokota, T. et al. (1986) Proc. Natl. Acad. Sci. 83:5894. 4. Redfield, C. et al. (1991) Biochemistry 30:11029. 5. Ramirez, F. et al. (1988) J. Immunol. Meth. 221:141. 6. Leitenberg, D. and T.L. Feldbush (1988) Cell. Immunol. 111:451. 7. Mosman, T.R. et al. (1987) J. Immunol. 138:1813. 8. Mueller, T.D. et al. (2002) Biochim. Biophys. Acta 1592:237. 9. Nelms, K. et al. (1999) Annu. Rev. Immunol. 17:701. 10. Paludan, S.R. (1998) Scand. J. Immunol. 48:459. 11. Corthay, A. (2006) Scand. J. Immunol. 64:93. 12. Ryan, J.J. et al. (2007) Crit. Rev. Immunol. 27:15. 13. Grone, A. (2002) Vet. Immunol. Immunopathol. 88:1. 14. Rosenberg, H.F. et al. (2007) J. Allergy Clin. Immunol. 119:1303. |
| Function | 重组人白介素-4，是促进B细胞增殖和Th2细胞分化的关键因子。适用于过敏与免疫调节研究、B细胞抗体产生实验及寄生虫免疫模型。 |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
FAQ
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IL-4主要调控哪类免疫反应？主导Th2型免疫反应，促进B细胞活化和抗体类别转换（如产生IgE），并诱导巨噬细胞向M2抗炎型极化。
在干细胞分化中有什么应用？与GM-CSF联合，可将造血祖细胞或单核细胞诱导分化为树突状细胞；也用于研究免疫微环境对干细胞行为的影响。
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