Recombinant Human FE1/FEN1 Protein, His Tag_天津卡梅德科技发展有限公司

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Recombinant Human FE1/FEN1 Protein, His Tag

Recombinant Human FE1/FEN1 Protein, His Tag

产品编号

KMH1081

别名

MF1, RAD2, FEN 1, flap structure specific endonuclease 1

规格

50ug
100ug

DATASHEET MSDS

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产品介绍

Alias	MF1, RAD2, FEN 1, flap structure specific endonuclease 1
Catalog Number	KMH1081
Molecular Name	FEN1
Species	Human
Host	E. coli
Size	50ug, 100ug
Protein Family	Other protein
Purity	≥90% as determined by SDS-PAGE
Purification	Affinity Purification
Endotoxin	Please contact our customer service for more information.
Formulation	PBS
Background	The protein encoded by this gene removes 5 overhanging flaps in DNA repair and processes the 5 ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5 end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.
Storage Condition	Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles.
Shipping Condition	This product is shipped on ice packs or dry ice.
Molecular Weight	41.8 kDa
Note	仅供科研使用

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