Human B7-H3 Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human B7-H3 Protein, hFc Tag

Human B7-H3 Protein, hFc Tag

产品编号

KMP2869

别名

共刺激分子蛋白, Human B7-H3 Protein, hFc Tag, B7-H3

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	共刺激分子蛋白, Human B7-H3 Protein, hFc Tag, B7-H3
Catalog Number	KMP2869
Product Description	The Human B7-H3 Protein(KMP2869) is produced in HEK293 Cells. The target gene encoding the human CD276 (Q5ZPR3-1) (Met1-Thr461) is expressed with the Fc region of human IgG1 at the C-terminus.
Molecular Name	B7-H3
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to either promote or inhibit T-cell responses in various experimental systems. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is a novel protein structurally related to the B7 family of ligands by the presence of a single set of immunoglobulin-V-like and immunoglobulin-C-like (VC) domains. Previous studies have correlated its overexpression with poor prognosis and decreased tumor-infiltrating lymphocytes in various carcinomas including uterine endometrioid carcinomas, and mounting evidence supports an immuno-inhibitory role in ovarian cancer prognosis. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	73.3 kDa

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