Human CTLA-4 Protein, hFc Tag, Avi Tag_天津卡梅德科技发展有限公司

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Human CTLA-4 Protein, hFc Tag, Avi Tag

Human CTLA-4 Protein, hFc Tag, Avi Tag

产品编号

KMP2865

别名

细胞毒性T淋巴细胞相关蛋白4, Human CTLA-4 Protein, hFc Tag, Avi Tag, CTLA-4

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	细胞毒性T淋巴细胞相关蛋白4, Human CTLA-4 Protein, hFc Tag, Avi Tag, CTLA-4
Catalog Number	KMP2865
Product Description	The Human CTLA-4 Protein(KMP2865) is produced in HEK293 Cells. The target gene encoding the Human CTLA4 (NP_005205.2)(Met1-Phe162) is expressed with a c-terminal Avi tagged Fc region of human IgG1 at the C-terminus (Fc-Avi). The expressed protein is biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
Molecular Name	CTLA-4
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Cytotoxic T-lymphocyte protein 4, also known as CTLA4 and CD152, is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members, CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role, CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular, recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells, termed regulatory T cells (Treg).
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	42.89 kDa

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