Human IL-18Rα Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human IL-18Rα Protein, hFc Tag

Human IL-18Rα Protein, hFc Tag

产品编号

KMP2855

别名

白细胞介素 18 受体 α, Human IL-18Rα Protein, hFc Tag, IL-18Rα

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	白细胞介素 18 受体 α, Human IL-18Rα Protein, hFc Tag, IL-18Rα
Catalog Number	KMP2855
Product Description	The Human IL-18Rα Protein(KMP2855) is produced in HEK293 Cells. The target gene encoding the human IL18R1 (NP_003846.1) (Met1-Arg329) is expressed with the Fc region of human IgG1 at the C-terminus.
Molecular Name	IL-18Rα
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein, and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in the lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from the brain, skeletal muscle, pancreas, and kidney. A high level of expression is found in Hodgkin disease cell lines. This receptor is specifically bound to interleukin 18 (IL18) and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	62.5 kDa

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