Human TREM-2 Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human TREM-2 Protein, hFc Tag

Human TREM-2 Protein, hFc Tag

产品编号

KMP2853

别名

髓系细胞触发受体2, Human TREM-2 Protein, hFc Tag, TREM-2

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	髓系细胞触发受体2, Human TREM-2 Protein, hFc Tag, TREM-2
Catalog Number	KMP2853
Product Description	The Human TREM-2 Protein(KMP2853) is produced in HEK293 Cells. The target gene encoding the human TREM2 (NP_061838.1) (Met1-Ser174) is expressed with the fused Fc region of human IgG1 at the C-terminus.
Molecular Name	TREM-2
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the basal ganglia, corpus callosum, medulla oblongata and spinal cord, and microglial cells are the major TREM2-producing cell type in the central nervous system (CNS). TREM2 may play a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. TREM2 forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. It also associates with the signal adapter protein, DAP12, which has a cytoplasmic ITAM, leading to the subsequent activation of cytoplasmic tyrosine kinases. TREM2 is both required and sufficient for competent uptake of apoptotic neuronal cells. TREM2 and TREM2-L form a receptor-ligand pair connecting microglia with apoptotic neurons, directing removal of damaged cells to allow repair. Deficiency of the adapter protein DAP12 or its associated receptor TREM2 is associated with abnormal osteoclast development in humans. Defects in TREM2 are causes of PLOSL, also known as NHD. In addition, TREM2 signaling is also an important pathway to promote healing of wounds in the colon where stem cell replacement is necessary.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	44.16 kDa

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