Human CEACAM5 Protein, His Tag, Avi Tag_天津卡梅德科技发展有限公司

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Human CEACAM5 Protein, His Tag, Avi Tag

Human CEACAM5 Protein, His Tag, Avi Tag

产品编号

KMP2850

别名

癌胚抗原相关的细胞粘附分子5, Human CEACAM5 Protein, His Tag, Avi Tag, CEACAM5

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	癌胚抗原相关的细胞粘附分子5, Human CEACAM5 Protein, His Tag, Avi Tag, CEACAM5
Catalog Number	KMP2850
Product Description	The Human CEACAM5 Protein(KMP2850) is produced in HEK293 Cells. The target gene encoding the human CEACAM5 (NP_004354.2) (Met1-Ala685) is expressed with a c-terminal Avi tagged polyhistidine tag at the C-terminus. The expressed protein is biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
Molecular Name	CEACAM5
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	CEACAM5, also known as CEA or D66e, belongs to the large CEACAM subfamily of the immunoglobulin superfamily. CEACAM5 is expressed primarily by epithelial cells, and is synthesized as a glycoprotein with an MW of 180 kDa comprising 60% carbohydrate. CEACAM5 contains one Ig-like V-type domain at the N-terminus, followed by six Ig-like C2-type domains and a GPI anchor, and exists as a homodimer. CEACAM5 and CEACAM6 are overexpressed in many cancers and are associated with adhesion and invasion. CEACAM5 can mediate cell-cell adhesion through homotypic and heterotypic interactions. It functions as a homotypic intercellular adhesion molecule and serves as a widely used tumor marker, since it is expressed at higher levels in tumorous tissues than in corresponding normal tissues. CEACAM5 has also been shown to contribute to tumorigenicity by inhibiting cellular differentiation. In addition, CEACAM5 is identified as the host receptor for the Dr family of adhesins of E.Coli, and the binding of E.coli Dr adhesins leads to dissociation of the CEACAM5 homodimer.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	74.59 kDa

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