Human CD20 Protein, TrxA Tag_天津卡梅德科技发展有限公司

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Human CD20 Protein, TrxA Tag

Human CD20 Protein, TrxA Tag

产品编号

KMP2823

别名

B淋巴细胞抗原CD20, Human CD20 Protein, TrxA Tag, CD20

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	B淋巴细胞抗原CD20, Human CD20 Protein, TrxA Tag, CD20
Catalog Number	KMP2823
Product Description	The Human CD20 Protein(KMP2823) is produced in E. coli. The target gene encoding the human MS4A1 (NP_068769.2) (Ile141-Ser188) is expressed with a TrxA tag at the N-terminus. The purified protein is biotinylated in vitro.
Molecular Name	CD20
Species	Human
Host	E. coli
Size	50ug, 100ug, 200ug
Purity	>80% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	CD20 (membrane-spanning 4-domains, subfamily A, member 1), also known as MS4A1, is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. CD20 / MS4A1 is expressed in all stages of B cell development except the first and last. CD20 / MS4A1 is present from pre-pre B cells through memory cells, but not on either pro-B cells or plasma cells. It is a B-lymphocyte surface molecule that plays a role in the development and differentiation of B-cells into plasma cells. CD20 / MS4A1may be involved in the regulation of B-cell activation and proliferation. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5(CVID5). CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections, and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells are usually in the normal range but can be very low.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	23.9 kDa

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