Human Cortisol Binding Globulin Protein, His Tag, Avi Tag_天津卡梅德科技发展有限公司

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Human Cortisol Binding Globulin Protein, His Tag, Avi Tag

Human Cortisol Binding Globulin Protein, His Tag, Avi Tag

产品编号

KMP2821

别名

皮质醇-结合球蛋白, Human Cortisol Binding Globulin Protein, His Tag, Avi Tag, Cortisol Binding Globulin

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	皮质醇-结合球蛋白, Human Cortisol Binding Globulin Protein, His Tag, Avi Tag, Cortisol Binding Globulin
Catalog Number	KMP2821
Product Description	The Human Cortisol Binding Globulin Protein(KMP2821) is produced in HEK293 Cells. The target gene encoding the human SERPINA6 (NP_001747.2) (Met1-Val405) is expressed with a c-terminal polyhistidine tagged Avi tag at the C-terminus. The expressed protein is biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
Molecular Name	Cortisol Binding Globulin
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Corticosteroid-binding globulin (CBG), also known as SerpinA6, is a non-inhibitory member of the serine proteinase inhibitor (serpin) superfamily. It is the high-affinity transport protein for glucocorticoids in vertebrate blood. CBG is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and CBG, and promotes a significant and local release of glucocorticoids (over 90% of them are bound to CBG in human plasma). In this context, CBG directs glucocorticoids to sites of inflammation, and plays in consequence a crucial role in efficient glucocorticoid action in physiology. The SerpinA6 protein is mainly secreted by the liver. This negative acute phase protein regulates free cortisol levels in the blood and distributes cortisol to its target tissues. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration, and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. There are three heritable, human CBG gene mutations that can reduce CBG-cortisol binding affinity and/or reduce circulating CBG levels.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	45.9 kDa

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