Human MCP2 Protein, SUMO Tag_天津卡梅德科技发展有限公司

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Human MCP2 Protein, SUMO Tag

Human MCP2 Protein, SUMO Tag

产品编号

KMP2819

别名

重组人单核细胞趋化蛋白2, Human MCP2 Protein, SUMO Tag, MCP2

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	重组人单核细胞趋化蛋白2, Human MCP2 Protein, SUMO Tag, MCP2
Catalog Number	KMP2819
Product Description	The Human MCP2 Protein(KMP2819) is produced in E. coli. The target gene encoding the human CCL8 (P80075-1) (Gln 24-Pro 99) is fused with the SUMO tag at the N-terminus.
Molecular Name	MCP2
Species	Human
Host	E. coli
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved locations in order to form their 3-dimensional shape. Some of the chemokines are considered pro-inflammatory which can be induced to recruit cells of the immune system to a site of infection during an immune response, while others are considered homeostatic and are implied in controlling the migration of cells during normal processes of tissue maintenance and development. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands-1 to 28. Chemokine ligand 8 (CCL8), also known as monocyte chemoattractant protein 2 (MCP-2), is a small cytokine belonging to the C-C chemokine family. CCL8 functions to activate different immune cells, including mast cells, eosinophils and basophils which are involved in allergic responses, monocytes, and T cells and NK cells which are involved in the inflammatory response. CCL8's ability achieves by binding to different cell surface receptors termed chemokine receptors including CCR1, CCR2B and CCR5. It has been reported that CCL8 is a potent inhibitor of HIV-1 by virtue of its binding to CCR5 which is one of the major co-receptors for HIV-1.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	21.7 kDa

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