Human NOTCH1 Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human NOTCH1 Protein, hFc Tag

Human NOTCH1 Protein, hFc Tag

产品编号

KMP2804

别名

缺口受体 1, Human NOTCH1 Protein, hFc Tag, NOTCH1

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	缺口受体 1, Human NOTCH1 Protein, hFc Tag, NOTCH1
Catalog Number	KMP2804
Product Description	The Human NOTCH1 Protein(KMP2804) is produced in HEK293 Cells. The target gene encoding the human NOTCH1 (NP_060087.3) (Ala19-Gln526) is expressed with the Fc region of human IgG1 at the C-terminus.
Molecular Name	NOTCH1
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	NOTCH1 is one of the four mammalian Notch receptors, which is involved in the Notch signaling pathway. Specifically, NOTCH1 promotes the proliferation of myogenic precursor cells, and the NICD domain of NOTCH1 can impair the regeneration of skeletal muscles.NOTCH1 is a prevalent signaling pathway in T cell acute lymphoblastic leukemia (T-ALL). The NOTCH signaling pathway is a conserved signaling cascade that regulates many aspects of development and homeostasis in multiple organ systems. The proto-oncogene NOTCH1 is frequently mutated in around 10% of patients with chronic lymphocytic leukemia (CLL). NOTCH1 mutations in oral squamous cell carcinoma (OSCC) frequently occur near the ligand-binding region. These mutations change the domain structure of this protein and affect the ligand-binding activity. When NOTCH1 is activated by ligand binding, the NOTCH1 intracellular domain (NICD) is cleaved from the cell membrane.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	79.7 kDa

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