Human TIGIT Protein, His Tag_天津卡梅德科技发展有限公司

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Human TIGIT Protein, His Tag

Human TIGIT Protein, His Tag

产品编号

KMP2791

别名

T细胞免疫球蛋白, Human TIGIT Protein, His Tag, TIGIT

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	T细胞免疫球蛋白, Human TIGIT Protein, His Tag, TIGIT
Catalog Number	KMP2791
Product Description	The Human TIGIT Protein(KMP2791) is produced in HEK293 Cells. The target gene encoding the extracellular domain of human TIGIT (NP_776160.2) (Met1-Pro141) with a C-terminal polyhistidine tag is expressed.
Molecular Name	TIGIT
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	TIGIT, also known as V-set and transmembrane domain-containing protein 3 (VSTM3) or V-set and immunoglobulin domain-containing protein 9 (VSIG9) is a new surface protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed on regulatory, memory, activated T cells and NK cells. It binds PVR with high affinity, and PVRL2 with lower affinity, but not PVRL3. Knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses, however, TIGIT inhibits NK cytotoxicity directly through its ITIM. TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. The binding of PVR to TIGIT on human dendritic cells enhanced the production of IL-1 and diminished the production of IL-12p4. Also, TIGIT counter inhibits the NK-mediated killing of tumor cells and protects normal cells from NK-mediated cytotoxicity thus providing an "alternative self" mechanism for MHC class I inhibition.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	28.81 kDa

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