Human Cripto Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human Cripto Protein, hFc Tag

Human Cripto Protein, hFc Tag

产品编号

KMP2786

别名

隐花色素, Human Cripto Protein, hFc Tag, Cripto

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	隐花色素, Human Cripto Protein, hFc Tag, Cripto
Catalog Number	KMP2786
Product Description	The Human Cripto Protein(KMP2786) is produced in HEK293 Cells. The target gene encoding the human TDGF1 (NP_003203.1) (Met1-Thr172) is expressed with the Fc region of human IgG1 at the C-terminus.
Molecular Name	Cripto
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Cripto/TDGF1 is a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family. EGF-CFC family member proteins share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. Before gastrulation, Cripto is asymmetrically expressed in a proximal–distal gradient in the epiblast, and subsequently is expressed in the primitive streak and newly formed embryonic mesoderm. These proteins play key roles in intercellular signaling pathways during vertebrate embryogenesis. Mutations in Cripto/TDGF1 can cause autosomal visceral heterotaxy. Cripto/TDGF1 is involved in left-right asymmetric morphogenesis during organ development. Cripto signalling is essential for the conversion of a proximal–distal asymmetry into an orthogonal anterior–posterior axis. The mechanism of inhibitory effects of the Cripto includes both cancer cell apoptosis, activation of c-Jun-NH(2)-terminal kinase and p38 kinase signaling pathways and blocking of Akt phosphorylation. Thus, Cripto is a unique target, and Immunohistochemistry to Cripto could be of therapeutic value for human cancers.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	42.7 kDa

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