Human CD73 Protein, His Tag, Avi Tag_天津卡梅德科技发展有限公司

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Human CD73 Protein, His Tag, Avi Tag

Human CD73 Protein, His Tag, Avi Tag

产品编号

KMP2785

别名

5'-核苷酸酶, Human CD73 Protein, His Tag, Avi Tag, CD73

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	5'-核苷酸酶, Human CD73 Protein, His Tag, Avi Tag, CD73
Catalog Number	KMP2785
Product Description	The Human CD73 Protein(KMP2785) is produced in HEK293 Cells. The target gene encoding the human NT5E (NP_002517.1) (Met1-Lys547) is expressed with a C-terminal polyhistidine tag followed by an Avi tag. The expressed protein is biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
Molecular Name	CD73
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM Tris, 120mM NaCl, 4mM Cacl2, 20% Glycerol, pH7.5
Background	5'-nucleotidase, also known as NT5E, NTE, and CD73, is a cell membrane protein that belongs to the 5'-nucleotidase family. CD73 is a glycosylphosphatidylinositol (GPI) anchored purine salvage enzyme expressed on the surface of human T and B lymphocytes. CD73 catalyzes the conversion of purine and pyrimidine ribo- and deoxyribonucleoside monophosphates to the corresponding nucleosides. CD73 serves as a costimulatory molecule in activating T cells. CD73 generated adenosine functions in cell signaling in many physiologic systems, including intestinal epithelium, ischemic myocardium, and cholinergic synapses. CD73 might mediate lymphocyte-stromal cell interactions or condition the local microenvironment to facilitate lymphocyte development and/or function. In CD73-depleted cells, surface levels of the leukocyte adhesion molecules ICAM-1, VCAM-1, and E-selectin increase. CD73 produces extracellular adenosine, which then acts on G protein-coupled purinergic receptors to induce cellular responses. CD73 has also been reported to regulate the expression of pro-inflammatory molecules in mouse endothelium.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	61.04 kDa

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