Human CD200 Protein, hFc Tag_天津卡梅德科技发展有限公司

>>

>>

>>

>

Human CD200 Protein, hFc Tag

Human CD200 Protein, hFc Tag

产品编号

KMP2767

别名

CD200细胞表面糖蛋白受体1, Human CD200 Protein, hFc Tag, CD200

规格

50ug
100ug
200ug

DATASHEET MSDS

立即询价加入询价列表大包装定制

产品介绍

Alias	CD200细胞表面糖蛋白受体1, Human CD200 Protein, hFc Tag, CD200
Catalog Number	KMP2767
Product Description	The Human CD200 Protein(KMP2767) is produced in HEK293 Cells. The target gene encoding the human CD200 (XP_003825138.1) (Met1-Gly232) is expressed with the Fc region of human IgG1 at the C-terminus.
Molecular Name	CD200
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. Signals delivered through the CD200:CD200R axis have been shown to play an important role in the regulation of anti-tumor immunity, and overexpression of CD200 has been reported in a number of malignancies, including CLL, as well as on cancer stem cells. The role of CD200-CD200R signaling in immune regulation of the central nervous system has become a popular field of research in recent years. Many studies have shown that there is a close correlation between CD200-CD200R, microglia activation, and Parkinson's disease (PD). The ability of CD200 to suppress myeloid cell activation is critical for maintaining normal tissue homeostasis but may also enhance the survival of migratory neoplastic cells. CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 has been characterized as an important immunoregulatory molecule, increased expression of which can lead to decreased transplant rejection, autoimmunity, and allergic disease. Elevated CD200 expression has been reported to be associated with poor prognosis in some human malignancies. Besides, CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	49.2 kDa

推荐产品

400-621-6806
614353794
周一至周五 9:00-18:00
0