Human Nectin 3 Protein, hFc Tag_天津卡梅德科技发展有限公司

>>

>>

>>

>

Human Nectin 3 Protein, hFc Tag

Human Nectin 3 Protein, hFc Tag

产品编号

KMP2755

别名

连接蛋白细胞粘附分子 3, Human Nectin 3 Protein, hFc Tag, Nectin 3

规格

50ug
100ug
200ug

DATASHEET MSDS

立即询价加入询价列表大包装定制

产品介绍

Alias	连接蛋白细胞粘附分子 3, Human Nectin 3 Protein, hFc Tag, Nectin 3
Catalog Number	KMP2755
Product Description	The Human Nectin 3 Protein(KMP2755) is produced in HEK293 Cells. The target gene encoding the human NECTIN3 (NP_056295.1) (Met1-Asp400) is expressed with the Fc region of human IgG1 at the C-terminus.
Molecular Name	Nectin 3
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Poliovirus receptor-related 3 (PVRL3), also known as Nectin-3 and CD113, is a member of the nectin family. PVRL3/Nectin-3 is an 83 kDa, type I transmembrane glycoprotein. Its precursor is 549 amino acids (aa) in length and contains an extended signal sequence of 57 aa, an extracellular domain (ECD) of 347 aa, a transmembrane segment of 21 aa, and a cytoplasmic region of 124 aa. Nectin-3 has three splicing variants, nectin-3alpha (biggest), -3beta (middle), and -3gamma (smallest). It is predominantly expressed in testis and placenta as well as in various cell lines, including epithelial cell lines. PVRL3/Nectin-3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/Nectin-2 at Sertoli-spermatid junctions. PVRL3/Nectin-3 is thus involved in the formation of cell-cell junctions, including adherens junctions and synapses. It has been shown to induce endocytosis-mediated down-regulation of PVR from the cell surface, resulting in the reduction of cell movement and proliferation.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	64.4 kDa

推荐产品

400-621-6806
614353794
周一至周五 9:00-18:00
0