Human Apolipoprotein E Protein, His Tag, Trx Tag_天津卡梅德科技发展有限公司

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Human Apolipoprotein E Protein, His Tag, Trx Tag

Human Apolipoprotein E Protein, His Tag, Trx Tag

产品编号

KMP2746

别名

载脂蛋白E, Human Apolipoprotein E Protein, His Tag, Trx Tag, Apolipoprotein E

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	载脂蛋白E, Human Apolipoprotein E Protein, His Tag, Trx Tag, Apolipoprotein E
Catalog Number	KMP2746
Product Description	The Human Apolipoprotein E Protein(KMP2746) is produced in E. coli. The target gene encoding the human APOE (P02649) (Lys 19-His 317) is fused with a Trx tag at the N-terminus. The purified protein is biotinylated in vitro.
Molecular Name	Apolipoprotein E
Species	Human
Host	E. coli
Size	50ug, 100ug, 200ug
Purity	>75% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Apolipoprotein E (ApoE) is a 34.2 kDa glycosylated protein with 299 amino acid residues. There are three isoforms in human (apoE2, apoE3, and apoE4) due to different amino acid residues at positions 112 and 158. ApoE is synthesized predominantly in the liver, but also by cells in the spleen, brain, lung, kidney, ovary, adrenal, and muscle tissues. Hepatic parenchyma cells are the main apoE producing cells in mammalian body, probably accounting for two thirds to three fourths of the plasma apoE . In the nervous system, apoE mRNA is present in neurons, astrocytes, ependymal cells, nonmyelinating Schwann cells, but not in microglia, oligodendroglia, choroidal cells, or myelinating Schwann cells. ApoE produced by mammalian cells exists in different forms, monomers, dimers, modified, unmodified, lipid-rich, and lipid-poor, and so forth. ApoE plays a double-role in immune responses. Both apoE containing lipoproteins and multimers of synthetic apoE peptides inhibited proliferation of cultured lymphocytes by inhibiting DNA synthesis and reducing phospholipid turnover in T cells. ApoE can also affect innate and acquired immune responses in vitro by its ability to suppress stimulation of cultured neutrophils. ApoE can bind lipopolysaccharide (LPS), attenuate the inflammatory response, and thus reduce LPS induced lethality. Injection of LPS stimulated higher expression of inflammatory cytokines like interleukin (IL)-1β, IL-12, and interferon-γ (IFN-γ), as well as IL-6.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	51.3 kDa

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