Human CD70 Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human CD70 Protein, hFc Tag

Human CD70 Protein, hFc Tag

产品编号

KMP2733

别名

肿瘤坏死因子配体超家族成员 7, Human CD70 Protein, hFc Tag, CD70

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	肿瘤坏死因子配体超家族成员 7, Human CD70 Protein, hFc Tag, CD70
Catalog Number	KMP2733
Product Description	The Human CD70 Protein(KMP2733) is produced in HEK293 Cells. The target gene encoding the extracellular domain of human CD70 (NP_001243.1) (Gln 39-Pro 193) is fused with the Fc region of human IgG1 at the N-terminus via a polypeptide linker.
Molecular Name	CD70
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor, CD27, is important in priming, effector functions, differentiation and memory formation of T-cells as well as plasma and memory B-cell generation. Tight control of CD70 expression is required to prevent lethal immunodeficiency. By selective transcription, CD70 is largely confined to activated lymphocytes and dendritic cells (DC). As a type II transmembrane receptor, CD70 is normally expressed on a subset of B, T and NK cells, where it plays a costimulatory role in immune cell activation. Immunohistochemical analysis of CD70 expression in multiple carcinoma types. The restricted expression pattern of CD70 in normal tissues and its widespread expression in various malignancies makes it an attractive target for antibody-based therapeutics. Investigations to exploit CD70 as a cancer target have lead to the identification of potential antibody-based clinical candidates.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	45.5 kDa

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