Human ASGR1 Protein, His Tag_天津卡梅德科技发展有限公司

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Human ASGR1 Protein, His Tag

Human ASGR1 Protein, His Tag

产品编号

KMP2725

别名

去唾液酸糖蛋白受体, Human ASGR1 Protein, His Tag, ASGR1

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	去唾液酸糖蛋白受体, Human ASGR1 Protein, His Tag, ASGR1
Catalog Number	KMP2725
Product Description	The Human ASGR1 Protein(KMP2725) is produced in HEK293 Cells. The target gene encoding the human ASGR1 isoform 1 (P07306) (Gln62-Leu291) is expressed with a polyhistidine tag at the N-terminus. The purified protein is biotinylated in vitro.
Molecular Name	ASGR1
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	The asialoglycoprotein receptor (ASGPR), an endocytotic cell surface receptor expressed by hepatocytes, is triggered by triantennary binding to galactose residues of macromolecules such as asialoorosomucoid (ASOR). ASGPR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family. It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGPR1(MHL-1) and a minor 51 kDa glycoprotein ASGR2 (MHL-2). ASGPR1 is synthesized as a type II transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, and an extracellular domain which contains two important structural regions. The first is a stalk domain that contributes to noncovalent oligomerization, and the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions. The research regarded that ASGPR1 could be targeted for anti- hepatitis B virus (HBV) drug development.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	28.8 kDa

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