Human SEMA3A Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human SEMA3A Protein, hFc Tag

Human SEMA3A Protein, hFc Tag

产品编号

KMP2720

别名

信号素3A, Human SEMA3A Protein, hFc Tag, SEMA3A

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	信号素3A, Human SEMA3A Protein, hFc Tag, SEMA3A
Catalog Number	KMP2720
Product Description	The Human SEMA3A Protein(KMP2720) is produced in HEK293 Cells. The target gene encoding the human SEMA3A (NP_006071.1) (Lys26-Phe546) is expressed with the Fc region of human IgG1 at the N-terminus.
Molecular Name	SEMA3A
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Semaphorins are a family of secreted and cell-bound signaling molecules defined by the presence of a common 5 aa Sema domain. They are best characterized in relation to axon guidance during development of the nervous system. The functions of Semaphorins 3A (SEMA3A) are mediated primarily through binding to the Neuropilin-1 (Npn-1) and Plexin-A1 coreceptor complex. Neuropilins lack a signaling-competent cytoplasetmic domain and ensure semaphorin binding, whereas the transmembrane receptor plexin mediates the intracellular response. As the first identified vertebrate semaphorin, SEMA3A functions either as a chemorepulsive agent inhibiting axonal outgrowth, or as a chemoattractive agent stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Its overexpression is associated with schizophrenia which is seen in various human tumor cell lines, and aberrant release is associated with the progression of Alzheimer's disease
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	87.7 kDa

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