Human B7-H4 Protein, mFc Tag_天津卡梅德科技发展有限公司

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Human B7-H4 Protein, mFc Tag

Human B7-H4 Protein, mFc Tag

产品编号

KMP2717

别名

含V区域T细胞激活抑制因子1, Human B7-H4 Protein, mFc Tag, B7-H4

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	含V区域T细胞激活抑制因子1, Human B7-H4 Protein, mFc Tag, B7-H4
Catalog Number	KMP2717
Product Description	The Human B7-H4 Protein(KMP2717) is produced in HEK293 Cells. The target gene encoding the human VTCN1 (NP_078902.2) (Phe29-Ala258) is expressed with the Fc region of mouse IgG1 at the C-terminus.
Molecular Name	B7-H4
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type-III membrane protein belonging to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. They provide costimulatory signals that regulate T cell responses. A soluble form of B7H4 has also been detected. B7X / VTCN1 / B7H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, B7X / VTCN1 / B7H4 plays an important role, together with regulatory T-cells(Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. B7X / VTCN1 / B7H4 is also involved in promoting epithelial cell transformation. This membrane protein can be up-regulated by IL6 / interleukin-6 and IL10 / interleukin-10 and inhibited by CSF2 / GM-CSF and IL4 / interleukin-4 on antigen-presenting cells.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	51.7 kDa

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