Human SFRP4 Protein, His Tag_天津卡梅德科技发展有限公司

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Human SFRP4 Protein, His Tag

Human SFRP4 Protein, His Tag

产品编号

KMP2716

别名

分泌型卷曲相关蛋白 4, Human SFRP4 Protein, His Tag, SFRP4

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	分泌型卷曲相关蛋白 4, Human SFRP4 Protein, His Tag, SFRP4
Catalog Number	KMP2716
Product Description	The Human SFRP4 Protein(KMP2716) is produced in CHO Cells. The target gene encoding the human SFRP4 (NP_003005.2) (Met1-VAL346) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	SFRP4
Species	Human
Host	CHO Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	SFRP family consists of five secreted glycoproteins in humans acting as extracellular signaling ligands. Each is approximately 3 amino acids in length and contains a cysteine-rich domain (CRD) that shares 3-5% sequence homology with the CRD of Frizzled (Fz) receptors, a putative signal sequence, and a conserved hydrophilic carboxy-terminal domain. SFRPs act as soluble modulators of Wnt signaling, counteracting Wnt-induced effects at high concentrations and promoting them at lower concentrations. SFRPs are able to bind Wnt proteins and Fz receptors in the extracellular compartment. The interaction between SFRPs and Wnt proteins prevents the latter from binding the Fz receptors. The Wnt pathway plays a key role in embryonic development, cell differentiation and cell proliferation. SFRP4 is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins called FZ domain and a NTR domain. Mouse SFRP4 is highly expressed in the ovary, and is localized to granulosa cells of periovulatory follicles and corpora lutea. It plays a critical role in placental development and implantation, and is also an important factor in the development of the decidual fibrinoid zone, and in trophoblast apoptosis.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	39 kDa

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