Human IgG1-Fc Protein_天津卡梅德科技发展有限公司

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Human IgG1-Fc Protein

Human IgG1-Fc Protein

产品编号

KMP2713

别名

免疫球蛋白G, Human IgG1-Fc Protein, IgG1-Fc

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	免疫球蛋白G, Human IgG1-Fc Protein, IgG1-Fc
Catalog Number	KMP2713
Product Description	The Human IgG1-Fc Protein(KMP2713) is produced in HEK293 Cells. The target gene encoding the IGHG1 (AAC82527.1) (Glu99-Lys330) (one aa mutation,103 Cys/Ser) is expressed. The purified protein is biotinylated in vitro.
Molecular Name	IgG1-Fc
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS
Background	As a monomeric immunoglobulin that is predominately involved in the secondary antibody response and the only isotype that can pass through the human placenta, Immunoglobulin G (IgG) is synthesized and secreted by plasma B cells, and constitutes 75% of serum immunoglobulins in humans. IgG antibodies protect the body against the pathogens by agglutination and immobilization, complement activation, toxin neutralization, as well as antibody-dependent cell-mediated cytotoxicity (ADCC). IgG tetramer contains two heavy chains (5 kDa ) and two light chains (25 kDa) linked by disulfide bonds, that is the two identical halves form the Y-like shape. IgG is digested by pepsin proteolysis into Fab fragment (antigen-binding fragment) and Fc fragment ("crystallizable" fragment). IgG1 is most abundant in serum among the four IgG subclasses (IgG1, 2, 3 and 4) and binds to Fc receptors (FcγR ) on phagocytic cells with high affinity. Fc fragment is demonstrated to mediate phagocytosis, trigger inflammation, and target Ig to particular tissues. Protein G or Protein A on the surface of certain Staphylococcal and Streptococcal strains specifically binds with the Fc region of IgGs, and has numerous applications in biotechnology as a reagent for affinity purification. Recombinant IgG Fc Region is suggested to represent a potential anti-inflammatory drug for treatment of human autoimmune diseases.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	26.1 kDa

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