Human EpCAM Protein, hFc Tag, Avi Tag_天津卡梅德科技发展有限公司

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Human EpCAM Protein, hFc Tag, Avi Tag

Human EpCAM Protein, hFc Tag, Avi Tag

产品编号

KMP2702

别名

上皮细胞粘附分子, Human EpCAM Protein, hFc Tag, Avi Tag, EpCAM

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	上皮细胞粘附分子, Human EpCAM Protein, hFc Tag, Avi Tag, EpCAM
Catalog Number	KMP2702
Product Description	The Human EpCAM Protein(KMP2702) is produced in HEK293 Cells. The target gene encoding the human EPCAM (NP_002345.2) (Met1-Lys265) is expressed with a C-terminal Fc region of human IgG1 tag followed by an Avi tag. The expressed protein is biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
Molecular Name	EpCAM
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type I transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	56 kDa

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