Human Angiopoietin-2 Protein, mFc Tag_天津卡梅德科技发展有限公司

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Human Angiopoietin-2 Protein, mFc Tag

Human Angiopoietin-2 Protein, mFc Tag

产品编号

KMP2695

别名

血管生成素 2, Human Angiopoietin-2 Protein, mFc Tag, Angiopoietin-2

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	血管生成素 2, Human Angiopoietin-2 Protein, mFc Tag, Angiopoietin-2
Catalog Number	KMP2695
Product Description	The Human Angiopoietin-2 Protein(KMP2695) is produced in HEK293 Cells. The target gene encoding the human ANGPT2 (NP_001138.1) (Met1-Gln248 and Lys275-Phe496 linked by a polypeptide linker) is expressed with the Fc region of mouse IgG2a at the C-terminus.
Molecular Name	Angiopoietin-2
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>85% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Angiopoietin-2 (ANG 2, or ANGPT2), is a member of the ANG family, which plays an important role in angiogenesis during the development and growth of human cancers. Both ANGPT-1 and ANGPT-2 appear to bind to the tyrosine kinase receptor, Tie-2, found primarily on the luminal surface of endothelial cells. ANG-2's role in angiogenesis generally is considered as an antagonist for ANG1, inhibiting ANG1-promoted Tie2 signaling, which is critical for blood vessel maturation and stabilization. ANG-2 modulates angiogenesis in a cooperative manner with another important angiogenic factor, vascular endothelial growth factor A. Genetic studies have revealed that ANG-2 also is critical in lymphangiogenesis during development. ANG-2 has multiple physiologic effects that regulate vascular tone, hormone secretion, tissue growth and neural activity. Several reports indicate that ANG-2 can induce neovascularization in experimental systems due to the expression of different growth factors such as angiopoietin 2, vascular endothelial factor, and its receptor, fibroblast growth factor, platelet derived growth factor, transforming growth factor beta and epidermal growth factor. In addition, ANG-2 is strongly expressed in the vasculature of many tumors and it has been suggested that ANG-2 may act synergistically with other cytokines such as vascular endothelial growth factor to promote tumor-associated Angiogenesis and tumor progression.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	80.3 kDa

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