Human ULBP1 Protein, His Tag, Avi Tag_天津卡梅德科技发展有限公司

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Human ULBP1 Protein, His Tag, Avi Tag

Human ULBP1 Protein, His Tag, Avi Tag

产品编号

KMP2690

别名

UL16结合蛋白-1, Human ULBP1 Protein, His Tag, Avi Tag, ULBP1

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	UL16结合蛋白-1, Human ULBP1 Protein, His Tag, Avi Tag, ULBP1
Catalog Number	KMP2690
Product Description	The Human ULBP1 Protein(KMP2690) is produced in HEK293 Cells. The target gene encoding the human ULBP1 (NP_079494.1) (Met1-Gly216) is expressed with a c-terminal polyhistidine tagged Avi tag at the C-terminus. The expressed protein is biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
Molecular Name	ULBP1
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	UL16-binding proteins (ULBP) or retinoic acid early transcripts-1 (RAET1) are ligands to the activating receptor, NKG2D. Ten members of the human ULBP/RAET1 gene family have been identified to encode for potentially functional proteins, and have tissue-specific expressions. ULBP1, also known as RAET1I and NKG2DL1, together with at least ULBP 2 and 3, are well-known ligands for NKG2D, and activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. ULBP1 is expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues including heart, brain, lung, liver and bone marrow, as well as some tumor cells. As an unconventional member of the MHC class I family, ULBP1 function in immune responses, especially in cancer and infectious diseases. Unlike other ULBP members, ULBP1 is able to interact with soluble CMV glycoprotein UL16 in CMV infected cells. The interaction with UL16 blocked the interaction with the NKG2D receptor, and thus might escape the immune surveillance. Furthermore, UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. The ULBP1 regulation may have implications for development of new therapeutic strategies against cancer cells.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	25.6 kDa

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