Human LIFR Protein, hFc Tag_天津卡梅德科技发展有限公司

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Human LIFR Protein, hFc Tag

Human LIFR Protein, hFc Tag

产品编号

KMP2678

别名

白血病抑制因子受体, Human LIFR Protein, hFc Tag, LIFR

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	白血病抑制因子受体, Human LIFR Protein, hFc Tag, LIFR
Catalog Number	KMP2678
Product Description	The Human LIFR Protein(KMP2678) is produced in HEK293 Cells. The target gene encoding the human LIFR (NP_002301.1) (Met1-Ser833) is expressed with the Fc region of human IgG1 at the C-terminus.
Molecular Name	LIFR
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	LIFR (leukemia inhibitory factor receptor) belongs to the family of cytokine receptors. LIFR forms a high-affinity receptor complex with gp130, which mediates the activity of LIF (leukemia inhibitory factor) and thus affects the differentiation, proliferation, and survival of a wide variety of cells in the adult and the embryo. Besides LIF, LIFR can also bind to and activate CNTF (ciliary neurotrophic factor) and CLC (Cardiotrophin Like Cytokine). Evidence showed that in the retina, LIFR activating LIF, CT-1, and Cardiotrophin Like Cytokine (CLC) are strongly upregulated in response to preconditioning with bright cyclic light leading to robust activation of signal transducer and activator of transcription-3 (STAT3) in a time-dependent manner. Further, blocking LIFR activation during preconditioning using a LIFR antagonist (LIF05) attenuated the induced STAT3 activation and also resulted in reduced preconditioning-induced protection of the retinal photoreceptors. These data demonstrate that LIFR and its ligands play an essential role in endogenous neuroprotective mechanisms triggered by preconditioning-induced stress. LIFR was newly found to be a suppressor of hepatocellular carcinoma (HCC), one of the world's top five causes of cancer-related deaths.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	116.1 kDa

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