Human BMP4 Protein_天津卡梅德科技发展有限公司

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Human BMP4 Protein

Human BMP4 Protein

产品编号

KMP2667

别名

骨形态发生蛋白4, Human BMP4 Protein, BMP4

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	骨形态发生蛋白4, Human BMP4 Protein, BMP4
Catalog Number	KMP2667
Product Description	The Human BMP4 Protein(KMP2667) is produced in E. coli. The target gene encoding the human BMP4 (P12644) (Ser293-Arg408, E399D) is expressed.
Molecular Name	BMP4
Species	Human
Host	E. coli
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	30% Acetonitrile, 1/1000 TFA
Background	BMP4 (bone morphogenetic protein-4)-directed differentiation of human embryonic stem cells (ESCd). Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP4), a member of the transforming growth factor (TGF-β) family of regulatory proteins, plays a crucial role in human malignancies. BMP4 treatment promoted HCC cells proliferation and induced autophagy. Mechanistic study revealed that the induction of autophagy by BMP4 was mediated through activating the JNK1/Bcl2 pathway. And the JNK1 inhibitor and knockdown of JNK1 could attenuate autophagy induced by BMP4 and eliminated BMP4-promoted HCC cells growth. BMP4 promoted HCC proliferation by autophagy activation through JNK1/Bcl-2 signaling.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	13.25 kDa

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