Human CD299 Protein_天津卡梅德科技发展有限公司

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Human CD299 Protein

Human CD299 Protein

产品编号

KMP2649

别名

C 型凝集素结构域家族 4,成员 M, Human CD299 Protein, CD299

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	C 型凝集素结构域家族 4,成员 M, Human CD299 Protein, CD299
Catalog Number	KMP2649
Product Description	The Human CD299 Protein(KMP2649) is produced in HEK293 Cells. The target gene encoding the human CLEC4M (NP_055072.3) (Ser78-Glu399) is expressed.
Molecular Name	CD299
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>80% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	C-type lectin domain family 4, member M, also known as DC-SIGNR and CLEC4M, is a type II integral membrane protein that is 77% amino acid identical to DC-SIGN, an HIV gp120-binding protein. Though the encoded gene located in the same chromosome, DC-SIGN is expressed solely on dendritic cells, while DC-SIGNR is predominantly found in liver sinusoidal endothelial cells and lymph node, as well as placental endothelium. DC-SIGNR exists as a homotetramer, and the tandem repeat domain, also called neck domain, mediates oligomerization. DC-SIGNR is regarded as a pathogen-recognition receptor involved in peripheral immune surveillance in liver, and probably mediates the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. DC-SIGNR appears to selectively recognize and bind many viral surface glycoproteins containing high mannose N-linked oligosaccharides in a calcium-dependent manner, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolAvirus glycoproteins, HCV E2, and human SARS coronAvirus protein S, as well as the cellular adhesion protein ICAM3. DC-SIGNR has been thought to play an important role in establishing HIV infection by enhancing trans-infection of CD4(+)T cells in the regional lymph nodes. It may affect susceptibility to HIV infection by a mechanism that is different in females and males. DC-SIGNR can bind to hepatitis C virus (HCV), and its polymorphism might affect HCV loads supporting the concept that DC-SIGNR contributes to HCV replication efficacy.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	37 kDa

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