Human FGFR4 Protein, His Tag_天津卡梅德科技发展有限公司

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Human FGFR4 Protein, His Tag

Human FGFR4 Protein, His Tag

产品编号

KMP2644

别名

成纤维细胞生长因子受体-4, Human FGFR4 Protein, His Tag, FGFR4

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	成纤维细胞生长因子受体-4, Human FGFR4 Protein, His Tag, FGFR4
Catalog Number	KMP2644
Product Description	The Human FGFR4 Protein(KMP2644) is produced in HEK293 Cells. The target gene encoding the extracellular domain (Met1-Asp369) of human FGFR4 (NP_002002.3) is fused with a polyhistidine tag at the C-terminus. The purified protein is biotinylated in vitro.
Molecular Name	FGFR4
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS
Background	Fibroblast growth factor receptor 4 (FGFR4) also known as CD334 antigen or tyrosine kinase related to fibroblast growth factor receptor, is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR4/CD334 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR4/CD334 preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. FGFR4/CD334 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4/CD334. Mutations in FGFR4/CD334 lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	40 kDa

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